Ch101. Bone Biomarkers

Ch101. Bone Biomarkers

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  12. Haugeberg G: Imaging of metabolic bone diseases, Best Pract Res Clin Rheumatol 22: 1127, 2008. PUBMED Abstract
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  16. Seibel MJ: Clinical application of biochemical markers of bone turnover, Arq Bras Endocrinol Metabol 50: 603, 2006. PUBMED Abstract
  17. Singer FR, Eyre DR: Using biochemical markers of bone turnover in clinical practice, Cleve Clin J Med 75: 739, 2008. PUBMED Abstract
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  23. Van de Lest CH, Van den Hoogen BM, Van Weeren PR: Changes in bone morphogenic enzymes and lipid composition of equine osteochondrotic subchondral bone, Equine Vet J Suppl 31: 31, 1999. PUBMED Abstract
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  30. Grafenau P, Eicher R, Ubelhart B, et al: General anaesthesia decreases osteocalcin plasma concentrations in horses, Equine Vet J 31: 533, 1999. PUBMED Abstract
  31. Price JS, Jackson B, Eastell R, et al: Age related changes in biochemical markers of bone metabolism in horses, Equine Vet J 27: 201, 1995. PUBMED Abstract
  32. Jackson BF, Smith RK, Price JS: A molecular marker of type I collagen metabolism reflects changes in connective tissue remodelling associated with injury to the superficial digital flexor tendon, Equine Vet J 35: 211, 2003. PUBMED Abstract
  33. Price JS, Jackson B, Gray JA, et al: Biochemical markers of bone metabolism in growing Thoroughbreds, Res Vet Sci 71: 1, 2001. PUBMED Abstract
  34. Jackson BF, Lonnell C, Verheyen K, et al: Gender differences in bone turnover in 2-year-old Thoroughbreds, Equine Vet J 35: 702, 2003. PUBMED Abstract
  35. Jackson BF, Blumsohn A, Goodship AE, et al: Circadian variation in biochemical markers of bone cell activity and insulin-like growth factor-1 in two-year-old horses, J Anim Sci 81: 2804, 2003. PUBMED Abstract
  36. Chapurlatt RD, Garnero P, Breart G, et al: Serum type I collagen breakdown product (serum CTX) predicts hip fracture risk in elderly women: the EPIDOS study, Bone 27: 283, 2000. PUBMED Abstract
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  38. Donabadien M, Van Weeren PR, Perona G, et al: Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse, Equine Vet J 40: 253, 2008. PUBMED Abstract
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  40. Price JS, Colwell A, Eastell R, et al: Urinary excretion of deoxypyridinoline as a marker of bone resorption in the Thoroughbred racehorse, Bone 13: 279, 1992.
  41. Jackson BJ Eastell R, Russell RG, et al: The measurement of pyridinium crosslinks in serum as a biochemical marker of bone turnover in horses, J Bone Miner Res 10: S339, 1995.
  42. Porr CA, Kronfeld DS, Lawrence LA, et al: Deconditioning reduces mineral content of the third metacarpal bone in horses, J Anim Sci 76: 1875, 1998. PUBMED Abstract
  43. Robins SP: Fibrillogenesis and maturation of collagens. In Siebel MJ, Robins SP, Bilezikian JP, eds: Dynamics of bone and cartilage metabolism, 1999, Academic.
  44. Black A, Schoknecht PA, Ralston, SL: Diurnal variation and age differences in the biochemical markers of bone turnover in horses, J Anim Sci 77: 75, 1999. PUBMED Abstract
  45. Hoekstra KE, Nielsen BD, Orth MW, et al: Comparison of bone mineral content and biochemical markers of bone metabolism in stall-versus pasture-reared horses, Equine Vet J 30: 601, 1999. PUBMED Abstract
  46. Kellerhouse PL, Brown C, Newall K, et al: Assessment of bone resorption marker assays in Thoroughbred horses, J Bone Miner Res 15: S526, 2000.
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  48. Nelson F, Dahlberg L, Laverty S, et al: Evidence for altered synthesis of type II collagen in patients with osteoarthritis, J Clin Invest 102: 2115, 1998. PUBMED Abstract
  49. Hannon R, Eastell R: Preanalytical variability of biochemical markers of bone turnover, Osteoporosis Int 11: 30, 2000. PUBMED Abstract
  50. Jackson BF, Blumsohn A, Goodship AE, et al: Circadian variation in biochemical markers of bone cell activity and insulin-like growth factor-I in two-year-old horses, J Animal Sci 81: 2804, 2003. PUBMED Abstract
  51. Carstanjen B, Hoyle NR, Gabriel A, et al: Evaluation of plasma carboxy terminal cross-linking telopeptides of type I collagen concentrations in horses, Am J Vet Res 64: 104, 2004. PUBMED Abstract
  52. Christgau S, Bitsch-Jensen O, Hanover Bjarnason NH, et al: Serum crosslaps for monitoring the response in individuals using antiresorptive therapy, Bone 26: 505, 2000. PUBMED Abstract
  53. Ginty F, Flynn A, Cashman KD: The effect of short-term calcium supplementation on biochemical markers of bone metabolism in healthy young adults, Br J Nutr 80: 437, 1998. PUBMED Abstract
  54. Maenpaa PH, Pirskanen A, Koskinen E, et al: Biochemical indicators of bone formation in foals after transfer from pasture to stables for the winter months, Am J Vet Res 49: 1990, 1988.
  55. Chiappe A, Gonzalez G, Frandinger E, et al: The influence of age and sex in serum osteocalcin levels in Thoroughbred horses, Arch Physiol Biochem 107: 50, 1999. PUBMED Abstract
  56. Vervuert I, Winkelsett S, Christmann L, et al: Evaluation of the influences of exercise, birth date, and osteochondrosis on plasma bone marker concentrations in Hannovarian Warmblood foals, Equine Vet J 68: 1319, 2007. PUBMED Abstract
  57. Billinghurst RC, Brama PAJ, van Weeren PR, et al: Significant exercise-related changes in serum levels of two biomarkers of collagen metabolism in young horses, Osteoarthritis Cartilage 11: 760, 2003. PUBMED Abstract
  58. Naylor KE, Iqbal P, Ledius C, et al: The effect of pregnancy on bone density and bone turnover, J Bone Miner Res 15: 129, 2000. PUBMED Abstract
  59. Davicco MJ, Faulconnier Y, Coxham V, et al: Systemic bone growth factors in light breed mares and their foals, Arch Int Physiol Biochin Biophys 102: 115, 1994. PUBMED Abstract
  60. Venken K, Callewaert F, Boonen S, et al: Sex hormones their receptors and bone health, Osteoporosis Int 19: 1517, 2008. PUBMED Abstract
  61. Jackson BF, Dyson PK, Hattersley RD, et al: Relationship between stages of the estrous cycle and bone cell activity in Thoroughbreds, Am J Vet Res 67: 1527, 2006. PUBMED Abstract
  62. Garnero P: Markers of bone turnover for prediction of fracture risk, Osteoporosis Int 11: 55, 2000. PUBMED Abstract
  63. Stepan JJ: Prediction of bone loss in menopausal women, Osteoporosis Int 11: 45, 2000. PUBMED Abstract
  64. Delmas PD: Markers of bone turnover for monitoring treatment of osteoporosis with antiresorptive drugs, Osteoporosis Int 11: 66, 2000. PUBMED Abstract
  65. Jackson BF, Dyson PK, Lonnell C, et al: Bone biomarkers and risk of fracture in two- and three-year-old Thoroughbreds, Equine Vet J 41: 410, 2009. PUBMED Abstract
  66. Price J: Unpublished data, 2009.
  67. McIlwraith CW: Personal communication, 2009.
  68. Verheyen KL, Henley WE, Price JS, et al: Training-related factors associated with dorsometacarpal disease in young Thoroughbred racehorses in the UK, Equine Vet J 37: 442, 2005. PUBMED Abstract
  69. Jackson BF, Lonnell C, Verheyen KL, et al: Biochemical markers of bone metabolism and risk of dorsal metacarpal disease in 2-year-old Thoroughbreds, Equine Vet J 37: 87, 2005. PUBMED Abstract
  70. Ytrehus B, Carlson CS, Ekman S: Etiology and pathogenesis of osteochondrosis, Vet Pathol 44: 429, 2007. PUBMED Abstract
  71. Price JS, Jackson B, Gray J, et al: Serum levels of molecular markers in growing horses: the effects of age, season, and orthopaedic disease, Trans Orthop Res Soc 22: 587, 1997.
  72. Billinghurst RC, Brama PAJ, van Weeren PR, et al: Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals, Am J Vet Res 65: 143, 2004. PUBMED Abstract
  73. Dyson PK, Jackson BF, Pfeiffer DU, et al: Days lost from training in two and three year old Thoroughbreds: a survey of seven UK training yards, Equine Vet J 40: 650, 2008. PUBMED Abstract
  74. Kawcak CE, McIlwraith CW, Norrdin RW, et al: The role of subchondral bone in joint disease: a review, Equine Vet J 33: 120, 2001. PUBMED Abstract
  75. Fuller CJ, Barr AR, Sharif M, et al: Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of the markers with articular cartilage damage, Osteoarthritis Cartilage 9: 49, 2001. PUBMED Abstract
  76. Kawcak CE: Effect of loading on subchondral bone of the equine carpal and metacarpophalangeal joints, PhD dissertation, Colorado, 1998, Colorado State University.
  77. Frisbie DD, Al-Sobayil F, Billinghurst RC, et al: Serum fluid markers distinguish exercise from osteoarticular pathology, Proc Am Assoc Equine Pract 49: 116, 2003.
  78. Frisbie DD, Al-Sobayil F, Billinghurst RC, et al: Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses, Osteoarthritis Cartilage 16: 1196, 2008. PUBMED Abstract
  79. Lanyon LE: Functional strain in bone tissue, J Biomech 20: 1083, 1997.
  80. Price JS, Jackson B, Eastell R, et al: The response of the equine skeleton to physical training: a biochemical study in horses, Bone 17: 221, 1995. PUBMED Abstract
  81. Jackson BF, Eastell R, Goodship AE, et al: Biochemical markers of bone metabolism reflect rapid adaptive responses in the skeleton of treadmill exercised two-year-old Thoroughbreds associated with changes in circulating insulin-like growth factor I, Am J Vet Res 64: 1549. 2003.
  82. Nielsen BD, Potter GD, Greene L, et al: Characterisation of changes related to mineral balance and bone metabolism in the young racing Quarter horse, J Equine Vet Sci 18: 190, 1998.
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  84. Vervuert I, Coenen M, Wedemeyer U, et al: Biochemical markers of bone activity in young Standardbred horses during different types of exercise and training, J Vet Med A Physiol Pathol Clin Med 49: 396, 2002. PUBMED Abstract
  85. Caron JP, Peters TL, Hauptman JG, et al: Serum concentrations of keratan sulphate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to Standardbred horses during race training, Am J Vet Res 63: 1106, 2002. PUBMED Abstract
  86. Fenton JI, Orth MW, Chelebek-Brown KA, et al: Effect of longeing and glucosamine supplementation on serum markers of bone and joint metabolism in yearling quarter horses, Can J Vet Res 63: 288, 1999. PUBMED Abstract
  87. Geor R, Hope E, Lauper L, et al: Effect of glucocorticoids on serum osteocalcin concentration in horses, Am J Vet Res 56: 1201, 1995. PUBMED Abstract
  88. Lepage OM, Laverty S, Marcoux M, et al: Serum osteocalcin concentration in horses treated with triamcinolone acetonide, Am J Vet Res 54: 1209, 1993. PUBMED Abstract
  89. Fenton JI, Orth, MW, Chelebek-Brown KA, et al: Effect of longeing and glucosamine supplementation on serum markers of bone and joint metabolism in yearling quarter horses, Can J Vet Res 63: 288, 1999. PUBMED Abstract
  90. Price JS, Jackson B, Noble GK, et al: Growth hormone administration increases bone turnover in horses, J Endocrinol 164: 129, 2000.
  91. Delguste C, Amory H, Doucet M, et al: Pharmacological effects of tiludronate in horses after long-term immobilization, Bone 41: 414, 2007. PUBMED Abstract