Ch63. Gene Therapy

Ch63. Gene Therapy

  1. Anderson WF: Human gene therapy, Nature 392:25, 1998. PUBMED Abstract
  2. Martin P, Thomas S: The commercial development of gene therapy in Europe and the USA, Hum Gene Ther 9:87, 1998. PUBMED Abstract
  3. Frisbie D, McIlwraith C: Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis, Clin Orthop 375S:S273, 2000. PUBMED Abstract
  4. Frisbie D, Ghivizzani S, Robbins P: Treatment of experimental equine osteoarthritis by an in vivo delivery of the equine interleukin-1 receptor antagonist gene, Gene Ther 9:12, 2009.
  5. Haupt J, Frisbie D, McIlwraith C, et al: Duel transduction of interleukin-like growth-factor-1 and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model, J Orthop Res 23:118, 2005. PUBMED Abstract
  6. Morrissey S, Frisbie D, Robbins P, et al: IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects, Clin Orthop 462:221, 2007. PUBMED Abstract
  7. Southwood L, Frisbie D, Kawcak C, et al: Delivery of growth factors using gene therapy to enhance bone healing, Vet Surg 33:565, 2004. PUBMED Abstract
  8. Nixon A, Haupt J, Frisbie D, et al: Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-1/interleukin-1 receptor antagonist therapy, Gene Ther 12:177, 2005. PUBMED Abstract
  9. Southwood L, Kawcak C, McIlwraith C, et al: Evaluation of Ad-BMP-2 enhancing fracture healing in an infected non-union fracture rabbit model, J Orthop Res 22:66, 2004. PUBMED Abstract
  10. Levick J: Blood flow and mass transport in synovial joints. In Renkin EM, Michel CC, et al, editors: Handbook of physiology, The cardiovascular system, Baltimore, 1984, American Physiology Society.
  11. Frisbie D, McIlwraith C: Gene therapy. Future therapies in osteoarthritis, Vet Clin North Am Equine Pract 17:233, 2001. PUBMED Abstract
  12. Otani K, Nita I, Macaulay W, et al: Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy, J Immunol 156:3558, 1996. PUBMED Abstract
  13. Arend W, Dayer J: Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis, Arthritis Rheum 33:305, 1990. PUBMED Abstract
  14. Arend W, Dayer J: Inhibition of the production and effects of interleukin-l and tumor necrosis factor alpha in rheumatoid arthritis, Arthritis Rheum 38:151, 1995. PUBMED Abstract
  15. Wood D, Ihrie E, Hamerman D: Release of interleukin-l from human synovial tissue, Arthritis Rheum 28:853, 1991.
  16. Caron J, Fernandes JC, Martel-Pelletier J, et al: Chondroprotective effects of intra-articular injections of interleukin-1 receptor antagonist in experimental osteoarthritis, Arthritis Rheum 39:1535, 1996. PUBMED Abstract
  17. Bandara G, Mueller G, Galea-Lauri J, et al: Intra-articular expression of biologically active interleukin-I receptor antagonist protein by ex vivo gene transfer, Proc Natl Acad Sci U S A 90:10764, 1991.
  18. Howard R, McIlwraith C, Trotter GW, et al: Cloning of equine interleukin 1 receptor antagonist and determination of its full-length cDNA sequence, Am J Vet Res 59:712, 1998. PUBMED Abstract
  19. Frisbie D, McIlwraith C: Evaluation of gene therapy as a treatment for equine traumatic arthritis. A species with clinical disease, Clin Orthop Rel Res 3795:5273, 2000. PUBMED Abstract
  20. Frisbie D, McIlwraith C: The effects of triamcinolone acetate on an in vivo equine osteochondral fragment exercise model, Equine Vet J 29:349, 1997. PUBMED Abstract
  21. Frisbie D, Kawcak C, Trotter G, et al: The effects of 6-alpha methylprednisolone acetate on an in vivo equine osteochondral fragment exercise model, Am J Vet Res 12:1619, 1998. PUBMED Abstract
  22. Goodrich L, Choi B, DudaCarbone B, et al: High-efficiency gene targeting to mammalian joint tissue using cell-complimentary adeno-associated viral vector serotypes, Mol Ther 13:S191, 2006.
  23. Goodrich L, Choi B, DudaCarbone B, et al: Serotype-specific transduction of equine joint tissue by self-complementary AAV vectors, Human Gene Therapy 20:1697, 2009. PUBMED Abstract
  24. Goodrich L, Brower-Toland P, Warnick L, et al: Direct adenovirus-medial IGF-1 gene transduction of synovium induces persisting synovial fluid IGF-1 ligand elevation, Gene Ther 13:1253, 2006. PUBMED Abstract
  25. Goodrich L, Hidaka C, Robbins P, et al: Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model, J Bone Joint Surg Br 89:672, 2007. PUBMED Abstract
  26. Haupt J, Frisbie D, McIlwraith C, et al: Dual transduction of insulin-like growth factor-1 and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model, J Orthop Res 23:118, 2005. PUBMED Abstract
  27. Nixon A, Haupt J, Frisbie D, et al: Gene-mediated restoration of cartilage matrix for combination insulin-like growth factor-1/interleukin-1 receptor antagonist therapy, Gene Ther 12:177, 2005. PUBMED Abstract
  28. Morrisset S, Frisbie D, Robbins P, et al: IL-1Ra.IGF-1 gene therapy modulates repair of microfractured chondral defects, Clin Orthop 462:221, 2007. PUBMED Abstract
  29. Southwood L, Frisbie D, Kawcak C, et al: Delivery of growth factors using gene therapy to enhance bone healing, Vet Surg 33:565, 2004. PUBMED Abstract
  30. Southwood L, Kawcak C, McIlwraith C, et al: Evaluation of Ad-BMP-2 enhancing fracture healing in an infected non-union fracture rabbit model, J Orthop Res 22:66, 2004. PUBMED Abstract